Introduction: Gastrointestinal tract is the most commonly affected extranodal non-Hodgkin  lymphoma and about 60% of cases occur in the stomach. Primary gastric lymphoma ( LGP ) is defined as lymphoid neoplasia affecting stomach only  and can involve the lymph nodes, but not mediatinal or retroperitoneum.

Materials and Methods: A review of 5 medical records of patients treated in the National Oncology Institute with Primary Gastric Lymphoma. Chemotherapy protocols, time course and response  to standard treatment were analyzed, and so surgery as a complementary o definitive treatment in patients who did not respond to initial treatment.

Result: Four of five patients had Helicobacter pylori positivity ( blood) and received treatment. CT scan of theree patients reported asymmetric wall thickening of stomach, the esophagus-gastroscopy revealed various gastric mucosal lesions (localized or diffuse). Pathology reported three patients with HIGH GRADE NON-HODGKIN GASTRIC LYMPHOMA and Two as DIFFUSE NON-HODGKIN LYMPHOMA B CELL, MALT TYPE. Three received  with 6 cycles of neoadyuvant chemotherapy with a duration between 6 to 8 months, after which endoscopic controls revealed persistent disease at pathology study,reason why surgical treatment was indicated. Two patients did not receive neoadjuvant treatment and were sent directly to surgery, one for active gastrointestinal bleeding tumor, and another 80-years old cardio patient who did not accept neoadyuvant treatment. The surgical treatment was total radical D-2 gastrectomy plus esophagus yeyuni anastomosis in Y Roux. The follow up shows that the five patients are still alive with a good oncologyc evolution, in periodic controls after four years the first one and eight months the last one after surgery. Only 1 patient developed anastomotic stenosis 1 month after surgery that resolved with endoscopic dilatations.

Conclutions: It is a need to establish, identify and ratify the protocols of the ION (SOLCA) for Primary gastric lymphoms treatment, reminding the importance of surgical treatment as alternative complementary o definitive treatment for patients who not respond to traditional chemo or radiotherapy.

Key Words.- Primary gastric lymphoma, Helicobacter pylori, gastrectomy, esophagus-gastroscopy, neoadyuvant.