Las complicaciones neurol�gicas de los pacientes con c�ncer sist�mico. frecuentemente se encuentran en� aumento con la diseminaci�n metast�sica cerebral. lo� cual afecta del 25 al 35% de todos los pacientes con c�ncer.
Las met�stasis cerebrales no controladas afectan seriamente� la calidad de vida en �stos enfermos, y; usualmente es la causa de muerte, a pesar de mantener un adecuado� control de la neoplasia primaria. Los focos primarios de dep�sitos metast�sicos en el sistema nervioso central m�s comunes son procedentes de pulm�n, mama, melanoma, ri�on y tracto gastrointestinal. El Instituto Oncol�gico Nacional� Dr. Juan Tanca Marengo �ION SOLCA es el mayor centro de referencia de patolog�as oncol�gicas en pa�s, en el Servicio de Neuro-Oncolog�a se realiz� una revisi�n de 67 expedientes cl�nico-radiol�gicos de pacientes portadores de c�ncer sist�mico con� 165 dep�sitos metast�sicos cerebrales y se analizan los sitios m�s frecuentes de la neoplasia primaria, distribuci�n� topogr�fica intracraneal de las met�stasis, s�ntomas y signos de presentaci�n cl�nica inicial y sus caracter�sticas� de neuroimagen. Los carcinomas de mama (40%) Y pulm�n (28%) son los tipos m�s frecuentes de c�ncer que desarrollaron dep�sitos metast�sicos cerebrales. Treinta casos presentaron met�stasis �nica (44.7%), y en este grupo
de enfermos los l�bulos frontales fueron las �reas m�s com�nmente comprometidas (33%), mientras que en el��grupo de los 37 casos con met�stasis m�ltiples (55.3%), el 37% de los dep�sitos metast�sicos fue en los l�bulos parietales (50 de 135 met�stasis). Cefalea, d�ficits motores focales y crisis convulsivas fueron las manifestaciones neurol�gicas
m�s comunes de presentaci�n cl�nica inicial. En los casos con c�ncer conocido, el estudio de neuroimagen
con mayor sensibilidad y especificidad para el diagn�stico de enfermedad metast�sica, fue la IRM reforzada con gadolinium.
En casos con sospecha de met�stasis cerebral, sin un c�ncer primario conocido, la presencia de una lesi�n
cerebral detectada por IRM no es un indicativo absoluto de enfermedad metast�sica.

Palabras claves: SNC, met�stasis �nica, met�stasis� m�ltiples, s�ntomas y signos, Te. IRM, c�ncer primario, c�ncer� desconocido.

Neurologic complications of patients with systemic cancer are constantly increasing with a cerebral metastatic dissemination, having an effect on the 25 to 35% of patients with cancer. Uncontrolled cerebral metastasis gravely affect the quality of life of these patients, and; it� is usually the cause of death, in spite of keeping enough control on the primary neoplasia. The most common primary� focuses of metastatic deposits in the central nervous� system are originated in the lung, breast, melanoma,
kidney, and gastrointestinal tract. Instituto Oncol�gico Nacional "Dr. Juan Tanca Marengo" ION-SOLCA is the main center of oncological pathology reference in the country. Sixty seven cl�nical-radiological records of systemic cancer carrier-patients with 165 cerebral metastatic deposit were reviewed at the Neuro-Oncology Service,� and the most frequent sites of primary neoplasia,
intracranial topographic distribution of metastasis, symptoms and signs of initial presentation with their neuroimage features are being examined. Breast carcinoma" (40%) and lung ones (28%) are the most common types of cancer devel oping cerebral metastatic deposito Thirty cases were reported with single metastasis (44.7%), and frontal lobes were the most commonly
compromised areas (33%) from this group of patients, while the 37% of metastatic deposit appeared in the parietal
lobes (SO out of 13S metastasis) in the 37-case group with multiple metastasis. Headache, focal motor deficit and convulsive cris is were the most common neurologic manifestations of clinical presentation. The reinforced MRI with gadolinium was the neuroimage study with most sensibility and specificity for the metastatic diagnosis in cases well-known primary cancer. In cases
suspected of cerebral metastasis with unknown primary cancer, the cerebral lesion detected through MRI is not an absol ute sign of metastatic disease.

Key words: CNS . Single metastasis . Multiple metastasis. Symptoms and sings . CT. MRI. Well-known� cancer. Unknown cancer.