Artículos Originales |
Introducción.- La quimioterapia ha sido empleada como tratamiento adyuvante, neoadyuvante y concomitante a la radioterapia con los objetivos de mejorar la sobrevida, en el cáncer de laringe, aumentando el control locorregional y sistémico. La quimioterapia concurrente a la radioterapia está siendo señalada como más efectiva que las otras dos modalidades. Palabras Claves: Cáncer de Laringe, quimioterapia, radioterapia. Palabras clave: Cáncer de Laringe, quimioterapia, radioterapia. |
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Abstract: | |
Introduction.- Chemotherapy has been used as adjuvant, neoadjuvant and concomitant to radiotherapy with the objectives of improving survival, cancer of the larynx, increasing the locoregional and systemic control. Concurrent chemotherapy to radiotherapy is being reported as more effective than the other two modalities.
Material and Methods.- We evaluated the clinical records of 55 patients ninitially diagnosed with laryngeal cancer, locally advanced, registered with the National Institute of Oncology in Havana in the period between March 2006 and June 2008.
Combined treatment was planned, which consisted of chemotherapy with cisplatin and 5-fluoracil, 3 cycles prior to radiotherapy, which would be administered, if proven a satisfactory response, with more than 50% reduction in tumor. The aim of this study was to assess the response to the treatment regimen proposed.
Results.- The distribution by age group most frequently treated were as between 61 and 70 years old, 25 patients, 45.45% and patients between 51 and 60 years old, with 15 patients, 27,27% The glottal larynx was the most common topographic location with 28 patients, accounting for 50.9% of alll cases. Objective responses were obtained in 94.54% patients, 42.5% patients retained their larynx.
Conclusions.- In most of our patients responses were obtained, with apparent complete response in 36 patients, 65.45 %, and partizl response in 16 cases, 29.09%.
Key words.- Laryngeal cancer, chemotherapy,
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Autor(es) : Dr. Carlos M. Díaz Salas, Dr. José Ramón Díaz Martínez, Dr. Lisandro Vila Martínez,
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