Artículos Originales |
Introducción.- Linfoma de Hodgkin (LH), representa el 14% de las malignidades linfoideas. La distribución de los subtipos histológicos varía de un país a otro; en Estados Unidos la esclerosis nodular es predominante y la celularidad mixta es más frecuente en América Central y Sudamérica. La tasa de cura excede el 80% con tratamiento, sin embargo en estadío avanzado, factores pronósticos pueden ayudar a identificar pacientes en riesgo de recaída que pueden ser incorporados a tratamientos intensificados. Palabras Claves: Linfoma de Hodgkin (LH), Quimioterapia (Qt), Respuesta Completa (RC), Sobrevida Global (SG). |
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Abstract: | |
Hodkin´s Lymphoma (LH) represents 14 % of the lymphoid malignancies. The distribution of histological subtypes varies from one country to another. In USA, nodular sclerosis is predominant 0and mixed cellularity is more frequent in Central America and Soth America. The cure rate exceeds 80% with tratment, nevertheless in advances stage prognostic factors may help to identy patients at risk of relapse that can be incorporated into intensified tratments. Material and Methods.- A 10 years - review was realized for LH of the adult at Oncological National Institute - SOLCA from Guayaquil , between January 1998 and December 2007. Results.- 142 cases were found. Nodular sclerosis was the most frequent subtype (51.4 ) 45,8% of patients presented B sympyoms, 4.9 % with extranodal location, 8.5 % with bone marrow infiltration. The rates of Complete Response (RC) to ABVD in our Institute come to 62.7% however when the chemotherapy (QT) was administered with adequate intensity, the RC rates exceeded 90%. It was found that 71.8 % of patients were missing either treatment or follow - up because we do not have an adequate program for that. Conclusions.- It is urgent to created conscience that the delay in the help at the appropiated moment means to lose the opportunity to cure patients, leading to greater expenditure of resources. Keywords.- Hodgkin´s lymphoma (HL) chemotherapy (CT) , complete resonse (CR), Overall Survival (OS)
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Autor(es) : Dr. Guillermo Paulson Vernaza, Dra. Fernanda Sánchez, Dra. Katherine García Matamoros, Dra. Katty Posligua León, Dra. Mayra Santacruz Maridueña,
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