Artículos Originales |
Introducción.- El cáncer de mama se relaciona con el estatus hormonal en la mujer. El estrógeno es el responsable, en la mayoría de los casos, en la proliferación y alteración genética de las células epiteliales de la glándula mamaria. Las variaciones en los genes relacionadas con el metabolismo del estrógeno son consideradas como factor de riesgo en el desarrollo del cáncer de mama. El gen CYP1A1 codifica enzimas de Clase I las cuales inician el metabolismo del estrógeno. El polimorfismo lle462Val (CIP1A1+2C) induce un cambio en el sitio catalítico de la enzima que ha sido relacionado con el riesgo en desarrollar cáncer de mama. Palabras Claves: Cáncer de mama, CYP1A1, estrógenos, lle462Val, receptores hormonales.
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Abstract: | |
Introduction.- Breast cancer is related to the hormonalstatus in women. Estrogen is responsible, in most cases, for the proliferation and alteration of epithelial cells in the mamary gland. variation in genes related to the estrogen metabolism are considered as risk factors in the developing breast cancer. The CYP1A1 gene encodes a Class I enzyme which initiates estrogen metabolism. lle462Val (CYP1A1*2C) polymorphism induces a change in the catalytic site of the enzyme and has been related with breast cancer risk.
Material and Methods.- To determine if there exists an association between the polymorphism and breast
cancer risk in Ecuadorian population, an allelic specific PCR was performed in 191 individuals: 82 had a previus diagnostic of breast cancer and 91 were considered as healthy controls. Data from the clinical history as estrogen, progesterone and HER2/neu
receptors along with genotypes were obtained and associated with the presence of the polymorphism by performing a chi-square and odd ratio tests.
Results.- No significant statiscal differences were found between cases and controls or among estrogen, progesterone and HER2 /neu receptors and genotypes. Because of the high numbetr of heterozygous lle/ Val individuals, significant statiscal differences were observed inside each group.
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Autor(es) : Biol. Andrés López-Cortés, Biol. Catherine Carrera, Biol. María José Muñoz, Dr. César Paz-y-Miño, Ing. Nadia Cumbal, Mtr. María Eugenia Sánchez,
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